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Introduction Glutathione is often called the master antioxidant for its critical role in cellular health and detoxification

Paradoxically, while this should acidify the cytosol (intracellular pH, pHi), neoplastic cells maintain pHi within 7.17.7 (versus ~7.2 in normal cells) through adaptive mechanisms: (i) upregulated SLC16A3 (encoding MCT4) extrudes lactate/H +

He had received treatment at Memorial Sloan Kettering

it required deliberate medicinal chemistry to shift binding affinity by 50-fold

To greatly speed up this discovery process, they developed a computer algorithm (nicknamed Peptide Predictor) to narrow the list of potential molecules that fit their criteria